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Juan J Calvete Selected Research

Snake Bites (Snake Bite)

7/2021Mutual enlightenment: A toolbox of concepts and methods for integrating evolutionary and clinical toxinology via snake venomics and the contextual stance.
1/2021Antivenomics and in vivo preclinical efficacy of six Latin American antivenoms towards south-western Colombian Bothrops asper lineage venoms.
1/2020Venomics and antivenomics of the poorly studied Brazil's lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Pará.
1/2020Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.
1/2019New insights into the phylogeographic distribution of the 3FTx/PLA2 venom dichotomy across genus Micrurus in South America.
1/2019Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka.
6/2018Toxin-resolved antivenomics-guided assessment of the immunorecognition landscape of antivenoms.
1/2018A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins.
1/2018The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms.
10/2017Third Generation Antivenomics: Pushing the Limits of the In Vitro Preclinical Assessment of Antivenoms.
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Juan J Calvete Research Topics

Disease

34Snake Bites (Snake Bite)
07/2021 - 11/2007
9Bites and Stings (Sting)
01/2020 - 08/2008
8Myotoxicity
10/2014 - 10/2008
6Neoplasms (Cancer)
06/2020 - 05/2003
5Hemorrhage
01/2020 - 02/2010
5Edema (Dropsy)
01/2017 - 10/2008
4Necrosis
09/2013 - 02/2010
3Adenocarcinoma of Lung
06/2020 - 09/2013
3Respiratory Paralysis
01/2019 - 08/2011
2Adenocarcinoma
06/2020 - 01/2014
2Paralysis (Palsy)
01/2020 - 01/2019
2Pain (Aches)
01/2020 - 08/2019
2Glioma (Gliomas)
06/2015 - 05/2013
2Melanoma (Melanoma, Malignant)
12/2014 - 08/2009
2Neglected Diseases
01/2014 - 08/2011
2Thrombosis (Thrombus)
04/2012 - 08/2006
1Type 2 Diabetes Mellitus (MODY)
06/2020
1Shock
01/2020
1Unconsciousness (Loss of Consciousness)
01/2020
1Body Weight (Weight, Body)
01/2020
1Hypotension (Low Blood Pressure)
01/2020
1Disseminated Intravascular Coagulation
04/2017
1Hemolysis
01/2017
1Myocardial Infarction
02/2013
1Gangrene
11/2011
1Neuroblastoma
11/2009
1Neoplasm Metastasis (Metastasis)
08/2009
1Wounds and Injuries (Trauma)
09/2007
1Cardiovascular Diseases (Cardiovascular Disease)
04/2007
1Newborn Respiratory Distress Syndrome
04/2006
1Autoimmune Diseases (Autoimmune Disease)
04/2006
1Liver Diseases (Liver Disease)
05/2004
1Liver Cirrhosis (Hepatic Cirrhosis)
05/2004

Drug/Important Bio-Agent (IBA)

39VenomsIBA
06/2020 - 11/2007
28Antivenins (Antivenoms)IBA
01/2021 - 08/2008
7Snake Venoms (Snake Venom)IBA
01/2018 - 02/2008
6Proteins (Proteins, Gene)FDA Link
06/2020 - 05/2004
4Biological ProductsIBA
07/2021 - 01/2015
4EnzymesIBA
01/2018 - 02/2012
4CoagulantsIBA
01/2017 - 10/2008
3Peptides (Polypeptides)IBA
06/2020 - 01/2014
3NeurotoxinsIBA
01/2019 - 08/2011
3DisintegrinsIBA
12/2014 - 01/2007
3CollagenIBA
05/2013 - 04/2006
2Serine Proteases (Serine Protease)IBA
06/2016 - 09/2002
2Metalloproteases (Metalloproteinases)IBA
04/2015 - 07/2012
2Laminin (Merosin)IBA
04/2015 - 12/2014
2Fibronectins (Fibronectin)IBA
12/2014 - 05/2013
2Three Finger ToxinsIBA
10/2014 - 08/2011
2IntegrinsIBA
02/2013 - 01/2007
2Phospholipases AIBA
02/2012 - 03/2010
2Integrin alpha1beta1IBA
08/2009 - 05/2003
1Phospholipases A2 (Phospholipase A2)IBA
06/2020
1Glucose (Dextrose)FDA LinkGeneric
06/2020
1Insulin (Novolin)FDA Link
06/2020
1Protein Isoforms (Isoforms)IBA
06/2020
1Chelating AgentsIBA
01/2020
1L-Amino Acid OxidaseIBA
01/2020
1Unithiol (DMPS)IBA
01/2020
1Factor X (Stuart Factor)IBA
01/2020
1ThrombinFDA Link
01/2020
1MetalsIBA
01/2020
1Pharmaceutical PreparationsIBA
01/2020
1ProteomeIBA
01/2020
1AcidsIBA
08/2019
1Cholinergic Agents (Cholinergics)IBA
01/2019
1TrypsinIBA
06/2016
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
06/2015
1nidogen (entactin)IBA
04/2015
1Collagen Type IV (Type IV Collagen)IBA
04/2015
1Collagen Type VIIBA
04/2015
1Extracellular Matrix ProteinsIBA
12/2014
1Collagen Type I (Type I Collagen)IBA
12/2014
1VitronectinIBA
12/2014
1Elapid Venoms (Cobra Venom)IBA
10/2014
1AntibodiesIBA
01/2014
1snake venom neurotoxin FIBA
01/2014
1AnticoagulantsIBA
10/2013
1ZincIBA
07/2012
1batimastat (BB 94)IBA
07/2012
1Prothrombin (Factor II)IBA
04/2012
1SolutionsIBA
08/2011
1Cytotoxins (Cytolysins)IBA
03/2011
1Toxic ActionsIBA
03/2010
1Immunoglobulin G (IgG)IBA
02/2010
1RNA Precursors (Precursor, mRNA)IBA
11/2009
1Nuclear Proteins (Protein, Nuclear)IBA
11/2009
1Integrin alpha2beta1IBA
08/2009
1Collagen ReceptorsIBA
08/2009
1Phospholipases (Phospholipase)IBA
10/2008
1Membrane LipidsIBA
09/2007
1Malondialdehyde (Propanedial)IBA
09/2007
1Integrin alpha ChainsIBA
01/2007
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2007
1CarboxypeptidasesIBA
08/2006
1DisulfidesIBA
08/2006
1Surface-Active Agents (Surfactants)IBA
04/2006

Therapy/Procedure

6Therapeutics
06/2020 - 04/2007
1Complementary Therapies (Alternative Medicine)
01/2018
1Intravenous Injections
01/2017